Diğer Seçilmiş Makaleler

Testis sparing surgery (2017)

Can Urol Assoc J. 2017 Mar-Apr;11(3-4):E100-E104. doi: 10.5489/cuaj.4016. Epub 2017 Mar 16.

Is testis-sparing surgery safe in small testicular masses? Results of a multicentre study.

Keske M1Canda AE2Yalcin S3Kilicarslan A1Kibar Y3Tuygun C4Onder E4Atmaca AF2Yildirim A5Ozkanli SS5Kandemir O6Kargi T7Sar M7Tugcu V7Resorlu B1Aslan Y8Sarikaya S9Boylu U10Cicek AF3Basar H6Tuncel A8Balbay MD11.

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Our goal was to evaluate benign and malignant lesions and testicular intraepithelial neoplasia (TIN) in the neighbouring normal-appearing testis tissue in men who underwent radical orchiectomy for testicular mass with a pathologic tumour size of ≤3cm.


In this retrospective, multicentre study, data of 252 patients from 11 different institutions were included. Patients were divided into three groups based on tumour size: Group 1 (0-1 cm; n=35), Group 2 (1.1-2cm; n=99), and Group 3 (2.1-3 cm; n=118). Benign lesions and TIN were sought in the neighbouring testicular tissue and compared between groups.


Mean patient age was 32.3 years. Benign lesions were reported in 54.3%, 33.3%, and 14.4% of Groups 1, 2, and 3, respectively (p<0.05 between groups). TIN was detected in 20%, 42.4%, and 41.5% of Groups 1, 2, and 3, respectively (p<0.05 for Group 1 vs. Groups 2 and 3; p>0.05 for Groups 2 vs. 3). Multifocality was detected in 8.6%, 4%, and 0% of Groups 1, 2, and 3, respectively (p<0.05 for both Group 1 vs. Group 3 and for Group 2 vs. Group 3; p>0.05 for Group 1 vs. Group 2). A tumour cutoff size of 1.5 cm was found to be significant for detecting benign tumour. TIN and multifocality rates were similar in patients with a tumour size of ≤1.5 vs. >1.5 cm (p>0.05).


Benign lesions and TIN in the neighbouring testis were significantly decreased and multifocality was increased in patients with a tumour mass size of ≤1 cm. Testis-sparing surgery should be performed with caution and a safety rim of normal tissue should also be excised.


Open stone surgery (2017)

Cent European J Urol. 2017 Jun 30;70(2):179-184. doi: 10.5173/ceju.2017.1205. Epub 2017 Mar 20.

Open stone surgery: a still-in-use approach for complex stone burden.

Çakici ÖU1Ener K2Keske M2Altinova S2Canda AE3Aldemir M2Ardicoglu A3.

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Urinary stone disease is a major urological condition. Endourologic techniques have influenced the clinical approach and outcomes. Open surgery holds a historic importance in the management of most conditions. However, complex kidney stone burden may be amenable to successful results with open stone surgery. In this article, we report our eighteen cases of complex urinary stone disease who underwent open stone removal.


A total of 1701 patients have undergone surgical treatment for urinary stone disease in our clinic between July 2012 and July 2016, comprising eighteen patients who underwent open stone surgery. Patients' demographic data, stone analysis results, postoperative clinical data, and stone status were evaluated retrospectively. The choice of surgical approach is mostly dependent on the surgeon's preference. In two patients, open surgery was undertaken because of perioperative complications.


We did not observe any Clavien-Dindo grade 4 or 5 complications. Three patients were managed with a course of antibiotics due to postoperative fever. One patient had postoperative pleurisy, one patient had urinoma, and two patients had postoperative ileus. Mean operation time was 84 (57-124) minutes and mean hospitalization time was 5.5 (3-8) days. Stone-free status was achieved in 15 patients (83.3%).


Endourologic approaches are the first options for treatment of urinary stone disease. However, open stone surgery holds its indispensable position in complicated cases and in complex stone burden. Open stone surgery is also a valid alternative to endourologic techniques in all situations.




Diabetes and urinary tract and interstitial cells (2014)

Cent European J Urol. 2014;67(4):366-74. doi: 10.5173/ceju.2014.04.art10. Epub 2014 Dec 5.

Does diabetes affect the distribution and number of interstitial cells and neuronal tissue in the ureter, bladder, prostate, and urethra of humans?

Canda AE1Dogan H2Kandemir O3Atmaca AF1Akbulut Z1Balbay MD4.

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The aim of this study was to investigate and compare the distribution and number of interstitial cells (ICs) and neuronal tissue in the ureter, bladder, prostate, and urethra of human patients with and without diabetes.


Human tissue was obtained from patients who had undergone radical cystectomy for bladder cancer (10 diabetic and 11 non-diabetic males). Interstitial cells were stained immunohistochemically with anti-human CD117 (c-kit) rabbit polyclonal antibody, Vimentin, and Connexin-43. Neural tissue was stained with synaptophysin. The number of ICs and neurons was evaluated and compared between the groups (diabetic versus non-diabetic).


The mean number of c-kit (+) ICs in bladder lamina propria was significantly decreased in diabetics (32.40 ±12.96 versus 57.18 ±25.37, p = 0.036). The mean number of ICs in the detrusor muscle was significantly decreased in diabetics (40.50 ±16.79 versus 64.55 ±22.08, p = 0.013). Between the groups, no significant differences were detected regarding the number of ICs at the level of the ureter, urethra, and prostate. No significant differences were detected regarding the number of nerves in the ureter, bladder, prostate, and urethra of both groups.


The number of ICs may be decreased in the lamina propria and detrusor muscle of the human bladder in diabetes. This can be an underlying cause of lower urinary tract (LUT) dysfunction in diabetics. Research into the development of drugs targeting or stimulating IC function in order to prevent diabetic LUT dysfunction is warranted.


Urological Research-2011


Efficiency of percutaneous nephrolithotomy in pediatric patients using adult-type instruments.

Dogan B, Atmaca AF, Canda AE, Isgoren AE, Akbulut Z, Balbay MD.

Urol Res. 2011 Aug 5. [Epub ahead of print]


Urology Journal-2011


Is positron emission tomography reliable to predict post-chemotherapy retroperitoneal lymph node involvement in advanced germ cell tumors of the testis?

Akbulut Z, Canda AE, Atmaca AF, Caglayan A, Asil E, Balbay MD.

Urol J. 2011 Spring;8(2):120-6.


The New Zealand Medical Journal-2010


BCG sepsis following inadvertent intravenous BCG administration for the treatment of bladder cancer can be effectively cured with anti-tuberculosis medications.

Akbulut Z, Canda AE, Atmaca AF, Cimen HI, Hasanoglu C, Balbay MD.

N Z Med J. 2010 Nov 5;123(1325):72-7.


World Journal of Urology-2010


Laparoscopic ureteral reimplantation: prospective evaluation of medium-term results and current developments.

Gözen AS, Cresswell J, Canda AE, Ganta S, Rassweiler J, Teber D.

World J Urol. 2010 Apr;28(2):221-6. Epub 2009 Jul 4.


Central European Journal of Medicine-2010

World Journal of Urology-2009


Prevention and management of ureteral injuries occurring during laparoscopic radical prostatectomy: the Heilbronn experience and a review of the literature.

Teber D, Gözen AS, Cresswell J, Canda AE, Yencilek F, Rassweiler J.

World J Urol. 2009 Oct;27(5):613-8. Epub 2009 Jun 10. Review.


Canadian Journal of Urology-2009


Testis sparing surgery for sequential bilateral testicular tumors.

Canda AE, Atmaca AF, Ozdemir AT, Akbulut Z, Balbay MD.

Can J Urol. 2009 Jun;16(3):4677-81. Review.


Central European Journal of Medicine-2009


Pharmacologic responses of the mouse urinary bladder.

Canda AE, Chapple CR, Chess-Williams R.

Cent Eur J Med. 2009 4(2):192-97. 


The British Journal of Urology International-2007


Role of Rho-kinase in contractions of ureters from rabbits with unilateral ureteric obstruction.

Turna B, Cinar MG, Canda AE, Orhan EC, Tiftik NR, Nazli O, Buyukafsar K.

BJU Int. 2007 Nov;100(5):1166-71. Epub 2007 Aug 17.


Urology Journal-2006


Current management of renal cell carcinoma and targeted therapy.

Canda AE, Kirkali Z.

Urol J. 2006 Winter;3(1):1-14.


The Scientific World Journal of Urology-2006


Superficial urothelial cancer in the prostatic urethra.

Kirkali Z, Canda AE.

ScientificWorldJournal. 2006 Feb 28;6:2603-10. Review.


International Urology and Nephrology-2006


Effects of finasteride on the vascular surface density, number of microvessels and vascular endothelial growth factor expression of the rat prostate.

Canda AE, Mungan MU, Yilmaz O, Yorukoglu K, Tuzel E, Kirkali Z.

Int Urol Nephrol. 2006;38(2):275-80.


European Urology-2006

Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma.

Mungan MU, Gurel D, Canda AE, Tuna B, Yorukoglu K, Kirkali Z.

Eur Urol. 2006 Jul;50(1):92-7; discussion 97. Epub 2006 Jan 6.


European Urology-2005


1,25 Dihydroxyvitamin D(3) receptor expression in superficial transitional cell carcinoma of the bladder: a possible prognostic factor?

Sahin MO, Canda AE, Yorukoglu K, Mungan MU, Sade M, Kirkali Z.

Eur Urol. 2005 Jan;47(1):52-7.


European Urology-2004


Conservative management of mucosal prostatic urethral involvement in patients with superficial transitional cell carcinoma of the bladder.

Canda AE, Tuzel E, Mungan MU, Yorukoglu K, Kirkali Z.

Eur Urol. 2004 Apr;45(4):465-9; discussion 469-70.


Current Opinion in Urology-2004


A rational approach to benign prostatic hyperplasia evaluation: recent advances.

Bhargava S, Canda AE, Chapple CR.

Curr Opin Urol. 2004 Jan;14(1):1-6. Review.


International Journal of Urology-2001


Testis sparing surgery for the treatment of a sequential bilateral testicular germ cell tumor.

Kirkali Z, Tüzel E, Canda AE, Mungan MU.

Int J Urol. 2001 Dec;8(12):710-2.